CELL POLARITY AND MOTILITY REFERENCES

The WAVE complex associates with sites of saddle membrane curvature

Pipathsouk A, Brunetti RM, Town JP, Breuer A, Pellett P, Marchuk K, Tran NHT, Krummel MF, Stamou D, Weiner OD.
J. Cell Biol., 220:e202003086 (2021).

Cell confinement reveals a branched-actin independent circuit for neutrophil polarity.

Graziano BR, Town JP, Sitarska E, Nagy TL, Fošnarič M, Penič S, Iglič A, Kralj-Iglič V, Gov NS, Diz- Muñoz A, Weiner OD
PLoS Biology, 17: e3000457 (2019).

Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.

Liu Z, Woo S, Weiner OD.
Development, 145: dev163535 (2018).

Chick cranial neural crest cells use progressive polarity refinement, no contact inhibition, to guide their motion.

Genuth MA, Allen CDC, Mikawa T, Weiner OD.
Dev Biol., 444: S252-S261. (2018).

Nodal signaling has dual roles in fate specification and directed migration during germ layer segregation in zebrafish.

Liu Z, Woo S, Weiner OD.
Development, 145: dev163535 (2018).

Chick cranial neural crest cells use progressive polarity refinement, no contact inhibition, to guide their motion.

Genuth MA, Allen CDC, Mikawa T, Weiner OD.
Dev Biol., 444: S252-S261. (2018).

A module for Rac temporal signal integration revealed with optogenetics.

Graziano BR, Gong D, Anderson KE, Pipathsouk A, Goldberg AR, Weiner OD.
J. Cell Biol., 216: 2515-2531 (2017).

Membrane tension acts through PLD2 and mTORC2 to constrain actin assembly during neutrophil migration.

Diz-Muñoz A, Thurley K, Chintamen S, Altschuler SJ, Wu LF, Fletcher DA, Weiner OD.
PLoS Biology, 14: e1002474 (2016).

GB regulates coupling between actin oscillators for cell polarity and directed migration.

Hoeller O, Toettcher JE, Cai H, Sun Y, Huang CH, Freyre M, Zhao M, Devreotes PN, Weiner OD.
PLoS Biology, 14: e1002381 (2016).

Probing yeast polarity with acute, reversible, optogenetic inhibition of protein function.

Jost AP, Weiner OD.
ACS Synthetic Biology, 4: 1077-85 (2015).

Homer3 regulates the establishment of neutrophil polarity.

Wu J, Pipathsouk A, Kizer-Gunnink A, Fusetti F, Alkema W, Liu S, ALtschuler SJ, Wu L, Kortholt A, Weiner OD.
Molecular Biology of the Cell, 26: 1629-39 (2015).

Self-organization of protrusions and polarity during eukaryotic chemotaxis.

Graziano BR, Weiner OD.
Current Opinion in Cell Biology, 30: 60-67 (2014).

How to understand and outwit adaptation.

Hoeller O, Gong D, Weiner OD.
Developmental Cell, 28: 607-616 (2014).

Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils.

Dandekar SN, Park J, Peng GE, Onuffer J, Lim WA, Weiner OD.
Philosophical Transactions of the Royal Society B, 368: 20130008 (2013).

Membrane tension maintains cell polarity by confining signals to the leading edge during neutrophil migration.

Houk A, Jilkine S, Mejean CO, Boltyanskiy R, Dufresne ER, Agenent S, Altschuler SJ, Wu LF, Weiner OD.
Cell, 148: 175-188 (2012).

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Diffusion, capture, and recycling of SCAR/WAVE and Arp2/3 complexes observed in cells with single-molecule imaging.

Millius A, Watanabe N, Weiner OD.
Journal of Cell Science, 125: 1165-1176 (2012).

A pharmacological cocktail for arresting actin dynamics in living cells.

Peng GE, Wilson SR, Weiner OD.
Molecular Biology of the Cell, 22: 3986-94 (2011).

Neutrophils establish rapid and robust Scar/WAVE complex polarity in an actin-dependent fashion.

Millius A*, Dandekar SN*, Houk AR*, Weiner OD.
Current Biology, 19(3): 253-259 (2009). (*equal contribution)

An actin-based wave generator organizes cell motility.

Weiner OD#, Marganski WA, Wu LF, Altschuler SJ, Kirschner MW#.
PLoS Biology, 5(9): e221 (2007). (#corresponding author) PDF

Hem-1 complexes regulate multiple polarity effectors at the leading edge of migrating neutrophils.

Weiner OD* , Rentel MC*, Ott A, Brown GE, Jedrychowski M, Yaffe MB, Gygi SP, Cantley LC, Bourne HR, Kirschner MW.
PLoS Biology, 4(2): e38 (2006). (*equal contribution)

A PI(3,4,5)P3/ Rho GTPase positive feedback loop regulates neutrophil polarity.

Weiner OD, Neilsen PO, Prestwich GD, Kirschner MW, Cantley LC, Bourne HR.
Nature Cell Biology, 4: 509-513 (2002).

Polarization of chemoattractant receptor signaling during neutrophil chemotaxis.

Servant, G*, Weiner OD*, Herzmark P, Bhalla T, Sedat JW, Bourne HR.
Science, 287: 1037-1040 (2000). (*equal contribution)

Spatial control of actin polymerization during neutrophil chemotaxis.

Weiner OD, Servant G, Welch MD, Mitchison TJ, Sedat JW, Bourne HR.
Nature Cell Biology, 1: 75-81 (1999).